The Role of Mediators in Sepsis Resolution

A substantial proportion of patients with sepsis get better, presumably as a consequence of appropriate antibiotic therapy, source control (if there is a localized site of infection), and transient physiological support of failed organ systems. What are the biological events that mediate this process? Can a better understanding of this process lead to novel therapeutic targets or strategies? What is the difference between those who recover and those who develop fixed MOF and succumb? A great deal is known about how infection induces a septic response, and how this septic response damages the host. Critical events in the triggering of sepsis are likely to include [2]: